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搜狐全球医讯 | Verywell: 女性打流感疫苗为何更易出现副作用?

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作者 | 周亦川

编辑 | 袁月

流感疫苗可有效应对流感季,会不会有副作用?Verywell网站近期发文介绍,女性比男性更容易出现疫苗副作用,但免疫效果也更强。

蒙特利尔大学研究员收集了18项研究共3.4万人数据,在接种疫苗七天内女性更容易出现注射部位疼痛,头痛、肌肉疼痛及发烧等反应,发生率约千分之115。年轻女性的注射部位及全身反应发生率较同龄男性高25%—29%,而老年女性则高出43%。

有些人发烧甚至达到影响正常生活的程度,女性风险是男性两倍。

专家解释,女性比男性更关注副作用症状,她们也更容易因此向医生求助;雌激素可能增强免疫反应,产生更多的功能性抗体,诱导更强的抗体水平,也带来更多的副作用,而雄激素可能抑制注射部位反应。包括新冠疫苗也存在类似的性别差异。

来源 / unsplash

因此,医护人员在为女性接种疫苗前可告知副作用风险,透明化传达可减轻接种者对副作用过度的焦虑与犹豫不决,增加对疫苗接种的信任度。我们还可以使用泰诺等退烧药减轻副作用。美CDC建议:这些药物只能接种后服用,在接种前吃药可能影响免疫系统的激活,降低药效。

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